Los Angeles-based artists Rhys Ernst and Zachary Drucker met three years ago, when Drucker was transitioning from male to female, and Ernst from female to male.

Artistic collaborators as well as “reverse heterosexual" life partners, on Thursday they’ll be at Carnegie Mellon for a talk titled “A Perfect X: Intersecting Transgender Perspectives in Film, Video and Performance.”

The pair will discuss their creative work apart and together — including their new experimental film collaboration, “She Gone Rogue” — and talk about gender and sexuality in their lives.

Ernst and Drucker regard gender and sexuality as distinct, and focus on fighting gender inequality.

Ernst is a filmmaker whose latest short, “The Thing,” premiered at Sundance. He’ll also discuss that film along with his “New Trans Cinema” approach, which seeks a more complex view of gender representation in film.

Drucker is a multimedia artist, working in performance, photography and more, whose work has been exhibited nationally and overseas.

While visiting CMU, they’ll tape an episode of Trans-Q Television, a web-based variety show being developed by students of Associate Art Professor Suzie Silver.

Their talk, which is free, will be held at 4:30 p.m. Thu., Oct. 18, at Porter Hall 100, on the CMU campus.